Nilesh Gaikwad, Ph. D., Founder and CEO

Served as a Director of Steroid Core at the NIH West Coast Metabolomics Center. His research has been focused in the areas of Metabolomics, Metabolism, Modulation of Metabolic Pathways, Mass Spectrometry and its Applications, Chemical Carcinogenesis, Food and Disease Biomarkers, and Biomarker Synthesis. Steroidomics platform that he has recently developed is the first, most advanced and unique in the world. Using this platform, we can now measure all classes (Androgens, Bile acids, DNA-adducts, Estrogens, Glucocorticoids, Mineralocorticoids, Neurosteroids, Oxysterols, Progestogens and Steroid-conjugates) of steroids with enhanced precision and sensitivity. He has patented this technology which is the foundation for the current R&D and service at the GSL. Dr. Gaikwad obtained his PhD degree from Indian Institute of Science and completed his postdoctoral training at UCSF and Harvard Medical School. Dr. Gaikwad left his tenure track professor position at UC Davis to start worlds first steroidomics company.

 

Selected Publications (Total 60)

1.The use and domestication of Theobroma cacao during the mid-Holocene in the upper Amazon
Sonia Zarrillo*, Nilesh Gaikwad*, Claire Lanaud*, Terry Powis, Christopher Viot, Isabelle Lesur, Olivier Fouet, Xavier Argout, Erwan     Guichoux, Franck Salin, Rey Loor Solorzano, Olivier Bouchez, Hélène Vignes, Patrick Severts, Julio Hurtado, Alexandra Yepez, Louis Grivetti, Michael Blake & Francisco Valdez.

Nature Ecology & Evolution In Press (2018)

*Authors contributed equally to this manuscript.

2. Sex-Dimorphic and Sex Hormone–Dependent Role of Steroid Sulfatase in Adipose Inflammation and Energy Homeostasis
Yuhan Bi Mengxi Jiang Weiwei Guo Xiudong Guan Meishu Xu Songrong Ren Da Yang Nilesh W Gaikwad Kyle W Selcer Wen Xie
Endocrinology, 159: 3365–3377, 2018.

3. Circulating Sex Steroids Co-regulate Adipose Tissue Immune Cell Populations in Healthy Men.
Rubinow KB, Chao J, Hagman D, Kratz M, Van Yserloo B, Gaikwad NW, Amory JK, Page ST.
Am J Physiol Endocrinol Metab. 313: E528–539, 2017

4. The Steroid Metabolome in Women with Premenstrual Dysphoric Disorder during GnRH Agonist-induced Ovarian Suppression: Effects of Estradiol and Progesterone Addback.

Tuong Vi Nguyen*, John M. Reuter*, Nilesh W. Gaikwad*, Daniel Rotroff, Alison Motsinger-Reif, Chris P. Smith, Lynnette K.                Nieman, David R. Rubinow, Rima Kaddurah- Daouk, and Peter J. Schmidt.

Translational Psychiatry, 7, e1193, 2017 .

*Authors contributed equally to this manuscript.

5. Skin-to-skin Contact after Birth and the Natural Co urse of Neurosteroid Levels in Healthy Term Newborns
Katherine R. McCallie, Nilesh W. Gaikwad, Martin E. Castillo Cuadrado, Monica Aleman, John E. Madigan, David K. Stevenson, and Vinod K. Bhutani
Journal of Perinatology, 37:591-595, 2017

6. Cautionary Tales about the Identification of Caffeinated Beverages in the Americas Adam King, Terry Powis and Nilesh W. Gaikwad* Journal of Archaeological Science 85, 30-40, 2017

7. Inflammatory Regulation of Steroid Sulfatase, A Novel Mechanism to Control Estrogen Homeostasis and Inflammation in Chronic Liver Disease. M. Jiang, M Klein, U M. Zanger, M K. Mohammad, M C. Cave, Nilesh W. Gaikwad, K W. Selcer, Y Guo, J He, X Zhang, Q Shen, W Qin, J Li, S Li, W Xie
Journal of Hepatology, 64:44-52. 2016

8. Estrogen sulfotransferase ablation sensitizes mice to sepsis.
Xie W, Chai X, Guo Y, Jiang M, Hu B, Li Z, Fan J, Deng M, Billiar T, Nilesh W. Gaikwad, Xu M, Lu P, Yan J, Fu H, Liu Y, Yu L, Huang M, Zeng S.

Nature Comm., 6:7979, 2015.

9. Intracrine androgens and AKR1C3 activation confer resistance to enzalutamide in prostate cancer
Chengfei Liu, Wei Lou, Yezi Zhu, Joy C. Yang, Nagalakshmi Nadiminty, Nilesh W. Gaikwad, C. P. Evans, Allen C. Gao.
Cancer Research, 75, 1413-1422, 2015.

10. Metabolic disturbance in the ATP binding cassette transporter Abcb6 deficient mice results in suppression of hepatic Cytochrome P450 activity.
H. Chavan, F. Li, R. Tessman, K. Mickey, K. Dorko, T. Schmitt, S. Kumer, Sumedha, Gunewardena, Nilesh Gaikwad, and Partha Krishnamurthy.
Journal of Biological Chemistry, 290: 7871-7886, 2015.

11. Estrogen sulfotransferase is an oxidative stress responsive gene that gender-specifically affects liver ischemia/reperfusion injury.
Yan Guo, Bingfang Hu, Hai Huang, Allan Tsung, Nilesh Gaikwad, Meishu Xu, Mengxi Jiang, Songrong Ren, Jie Fan, Timothy R. Billiar, Min Huang, and Wen Xie.
Journal of Biological Chemistry, 290:14754-64, 2015.

12. Hepatic Over-expression of Steroid Sulfatase Ameliorates Mouse Models of Obesity and Type 2 Diabetes through Sex-Specific Mechanisms
Mengxi Jiang, Jinhan He, Nilesh Gaikwad, Bin Zhang, Meishu W. Xu, Robert M. O’Doherty, Kyle W. Selcer, and Wen Xie
Journal of Biological Chemistry, 289:8086-8097, 2014.

13. Association between circulating endogenous androgens and insulin sensitivity changes with exercise training in midlife women.
Sridevi Krishnan, Mary B. Gustafson, Caitlin Campbell, Nilesh W. Gaikwad, Nancy L. Keim. Menopause, 21:967-74, 2014.

14. Mass spectrometry evidence for formation of estrogens-homocysteine conjugates: Estrogens can regulate homocysteine levels.
Nilesh W. Gaikwad
Free Radical Biology and Medicine. 65, 1447-1454, 2013.

15. Metabolomic profiling unravels DNA adducts in human breast that are formed from peroxidase mediated activation of estrogens to quinone methides.
Nilesh W. Gaikwad
PLoS One, 8: e65826, 2013.

16. Ultra performance liquid chromatography-tandem mass spectrometry method for profiling of steroid metabolome in human tissue.
Nilesh W. Gaikwad
Analytical Chemistry. 85:4951-4960, 2013.

17. Imbalanced estrogen metabolism in the brain: possible relevance to the etiology of Parkinson’s disease.
Gaikwad NW, Murman D, Beseler C, Zahid M, Rogan E, Cavalieri E.
Biomarkers. 16, 434-44, 2011.

18. Cacao use and the San Lorenzo Olmec.
Terry Powis, Ann Cyphers, Nilesh W. Gaikwad, Louis Grivetti and Kong Cheong.
Proceedings of the National Academy of Sciences, USA. 108, 8595–8600, 2011.