Nilesh Gaikwad, Ph. D., Founder and CEO

Dr. Gaikwad’s research has been focused in the areas of Steroidomics, Steroid Metabolism, Modulation of Steroid Metabolic Pathways, Archaeological Biomarkers, Biomarker Synthesis and Mass Spectrometry. Steroidomics platform that he has recently developed is the first, most advanced and unique in the world. He has patented this technology which is the foundation for the current R&D and service at the Gaikwad Steroidomcis Lab. Dr. Gaikwad left his tenure track professor position to start worlds first steroidomics company.

First paper on “Bileome” and “Bileomics”:   Gaikwad NW. Bileome: The Bile Acid Metabolome of Rat. BBRC. 533, 458-466, 2020.

Selected Publications 

1. The use and domestication of Theobroma cacao during the mid-Holocene in the upper Amazon. Sonia Zarrillo*, Nilesh Gaikwad*, Claire Lanaud*, et. al.  Nature Ecology & Evolution 2, 1879–1888, 2018.

*Authors contributed equally to this manuscript.

2. The Steroid Metabolome in Women with Premenstrual Dysphoric Disorder during GnRH Agonist-induced Ovarian Suppression: Effects of Estradiol and Progesterone Addback. Tuong Vi Nguyen*, John M. Reuter*, Nilesh W. Gaikwad*, Daniel Rotroff, Alison Motsinger-Reif, Chris P. Smith, Lynnette K.                Nieman, David R. Rubinow, Rima Kaddurah- Daouk, and Peter J. Schmidt. Translational Psychiatry, 7, e1193, 2017 .

*Authors contributed equally to this manuscript.

3. Estrogen sulfotransferase ablation sensitizes mice to sepsis. Xie W, Chai X, Guo Y, Jiang M, Hu B, Li Z, Fan J, Deng M, Billiar T, Nilesh W. Gaikwad, Xu M, Lu P, Yan J, Fu H, Liu Y, Yu L, Huang M, Zeng S.  Nature Comm., 6:7979, 2015.

4. Intracrine androgens and AKR1C3 activation confer resistance to enzalutamide in prostate cancer
Chengfei Liu, Wei Lou, Yezi Zhu, Joy C. Yang, Nagalakshmi Nadiminty, Nilesh W. Gaikwad, C. P. Evans, Allen C. Gao. Cancer Research, 75, 1413-1422, 2015.

5. Mass spectrometry evidence for formation of estrogens-homocysteine conjugates: Estrogens can regulate homocysteine levels. Nilesh W. Gaikwad
Free Radical Biology and Medicine. 65, 1447-1454, 2013.

6. Ultra performance liquid chromatography-tandem mass spectrometry method for profiling of steroid metabolome in human tissue.
Nilesh W. Gaikwad
Analytical Chemistry. 85:4951-4960, 2013.

7. Cacao use and the San Lorenzo Olmec.
Terry Powis, Ann Cyphers, Nilesh W. Gaikwad, Louis Grivetti and Kong Cheong.
Proceedings of the National Academy of Sciences, USA. 108, 8595–8600, 2011.